临床兽医系
左之才
时间:2011-09-20点击次数:作者:审稿:宋三多

姓名

左之才

政治面貌

中共党员

导师类型

博士生导师

办公地点

8-207

职称/职务

学院副院长/党委委员/三级教授/系主任

电子邮箱

ZZCJL@126.COM

研究方向

肉牛牦牛常见病研究与诊疗

1.研究目标:构建肉用牛养殖的生物安全防控体系

2.研究内容:

①肉用牛常见疾病轻简、快速诊断技术研发:开展肉用牛常见病快速分子检测方法研究,分子病理学诊断,研制适合于普通病现场诊断的技术产品。

②肉用牛常见疾病绿色防控制剂研制与应用:研制新型、绿色、环保的肉牛抗寄生虫蛋白制剂、疫苗、中药组合、矿物微量元素及维生素组合等;研发肉牛病原微生物、寄生虫卵环境净化消毒剂等。

③肉用牛常见疾病的智能诊疗技术研究:整合智慧牧场资源,监控肉用牛异常表现及指标情况,借助智能监测数据分析疾病发生及治疗用药效果等。

学术、技术组织任职/头衔

国家肉牛牦牛产业技术体系岗位科学家、农业部第七届化药评审专家、中国畜牧兽医学会内科学分会常务理事、四川肉牛创新团队岗位专家、四川农村日报社特约专家、筠连县人民政府肉牛产业发展顾问专家。

教育背景及工作经历

1.学习简历:

1994.09-1998.07,4556银河国际线路测试兽医专业本科学习,获学士学位;

2001.09-2004.07,4556银河国际线路测试临床兽医学专业研究生学习,获硕士学位;

2007.09-2012.06,4556银河国际线路测试临床兽医学专业研究生学习,获博士学位。

2.工作简历:

1998.07-2003.11,动物科技学院临床兽医学系助教;

2003.12-2008.11,动物科技学院临床兽医学系讲师;

2008.12-2013.11,4556银河国际线路测试临床兽医学系副教授、硕士生导师;

2013.10-至今,4556银河国际线路测试临床兽医学系主任;

2013.12-至今,4556银河国际线路测试临床兽医学系教授、博士生导师;

2014.10-2016.10期间挂职四川省广安市农业局党组成员、副局长;

2017年-至今,四川省肉牛创新团队岗位专家。

2021年-至今,国家肉牛牦牛产业技术体系岗位科学家。

教学课程

兽医临床诊断学、兽医内科学

人才培养情况

培养毕业研究生30余人,在读研究生12人。

科研项目

(近五年)

1.农业农村部-国家肉牛牦牛产业体系项目-常见病研究与诊疗(2021-2025),275万元

2.国家科技部-“国家十四五‘揭榜挂帅’项目”-牦牛生产现代管控关键技术创新与示范(2021-2024),80万元

3.横向合作-复方苯明西林乳房注入剂对干乳期奶牛亚临床型乳房炎防治效果的验证试验(2021-2022),30万元

4.横向合作-氟苯尼考注射液对自然感染牛呼吸道疾病治疗效果验证试验(2021-2022),63万元

5.横向合作-巴尔吡尔液体和赐力健粉剂对肉牛长途运输及生产性能的影响(2021-2022),34万元

6.市校合作-巴中市空山黄牛产业关键技术研发与应用(2021-2025),20万元

7. 主持完成四川省农业厅-国家现代农业产业技术体系四川肉牛创新团队“肉牛主要疾病防控技术研究与集成应用”项目(035Z0358,2017-2018);

8.参加四川省科技厅“三区”人才支持计划科技人员专项(2021-2023);

9.参加国家自然科学基金青年基金项目“丁酸通过NF-κB信号通路调控瘤胃上皮细胞单羧酸转运蛋白表达的影响机制研究”(31802086,2019-2021);

10. 参加四川省科技厅重点研发项目“肉牛清洁生产与种养循环关键技术的研究与示范”(2019YFQ0012,2019-2020);

11.参加四川省科技厅“三区”人才支持计划科技人员专项(2019);

12.参加四川省科技厅“三区”人才支持计划科技人员专项(2018);

13. 参加国家科技部“十三五”重点研发计划“优质肉牛高效安全养殖技术应用与示范”(2018YFD05018,2017-2020)项目,承担“犊牛早期培育技术研究与应用”子课题;

14. 参加四川省科技厅重点研发项目“优质肉牛高效安全生产技术研发与产业化示范”(2018NZ0002,2017-2020),承担“肉牛主要疾病防控技术集成与应用”子课题;

15. 参加四川省重大科技成果转化示范项目“规模化养殖场一种新发明的动物皮肤病控制技术研究”(16NZ0022,2015-2017)。

主要论著、

代表性论文

发表论文280余篇,其中以第一作者和通讯作者发表SCI 论文30篇、重要核心期刊42篇。主编、副主编《中国乡村兽医手册》等专著7部。

[1] QI J, LIN GAN, FANG J, et al. Beta-hydroxybutyrate: a Dual Function Molecular and Immunological Barrier Function Regulator [J]. Frontiers in Immunology, 2022, 6: 805881. (通讯作者,IF=7.561,2区top).

[2] CAI D, LIU L, TIAN B, et al. Dual-Role Ubiquitination Regulation Shuttling the Entire Life Cycle of the Flaviviridae [J]. Frontiers in Microbiology, 2022, 13: 835344. (通讯作者,IF=5.640,2区top)

[3]夏青,才冬杰,方静,等. β-羟丁酸对牛肺泡巨噬细胞促炎细胞因子释放的影响研究[J].浙江农业学报, 2022, 34(2):7.(通信作者,中文核心)

[4]樊利虹,王之盛,左之才,等.肉牛呼吸道皮特不动杆菌的生物学特性分析[J].浙江农业学报, 2022, 34(2):10.(中文核心)

[5] TIAN B, CAI D, LI W, et al. Identification and genotyping of a new subtype of bovine viral diarrhea virus 1 isolated from cattle with diarrhea [J].ARCHIVES OF VIROLOGY, 2021, 166(4): 1259-62. (通讯作者,IF=2.574)

[6] FANG J, YIN H, YANG Z, et al.Vitamin E protects against cadmium-induced sub-chronic liver injury associated with the inhibition of oxidative stress and activation of Nrf2 pathway [J].ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2021, 208: 111610. (IF=6.291, 1区top)

[7] FANG J, XIE S, CHEN Z, et al.Protective Effect of Vitamin E on Cadmium-Induced Renal Oxidative Damage and Apoptosis in Rats [J].BIOLOGICAL TRACE ELEMENT RESEARCH, 2021, 199(12): 4675-87. (IF=3.783)

[8] CUI Y, QI J, CAI D, et al.Metagenomics Reveals That Proper Placement After Long-Distance Transportation Significantly Affects Calf Nasopharyngeal Microbiota and Is Critical for the Prevention of Respiratory Diseases [J]. Frontiers in Microbiology, 2021, 12: 700704.(通讯作者,IF=5.640,2区top)

[9]LI Y, YANG Q, CAI D, et al. Resistin, a Novel Host Defense Peptide of Innate Immunity [J]. Frontiers in Immunology, 2021, 12: 699807 (通讯作者,IF=7.561,2区top)

[10] ZHANG Y-L, HUANG F-Y, GAN L-L, et al. High prevalence of bla and bla among ESBL producing E. coli isolates from beef cattle in China's Sichuan-Chongqing Circle [J]. Scientific Reports, 2021, 11(1): 13725.(通讯作者,IF=4.379)

[11] WANG F, ZUO Z, CHEN K, et al.Diet-Induced Obesity Mice Execute Pulmonary Cell Apoptosis via Death Receptor and ER-Stress Pathways after Infection [J].Oxidative Medicine and Cellular Longevity, 2020, 2020: 6829271. (IF=6.543)

[12] REN Z, GU X, FANG J, et al.Effect of intranasal instillation of Escherichia coli on apoptosis of spleen cells in diet-induced-obese mice [J].Scientific Reports, 2020, 10(1): 5109. (IF=4.379)

[13] QI J, CAI D, CUI Y, et al. Metagenomics Reveals That Intravenous Injection of Beta-Hydroxybutyric Acid (BHBA) Disturbs the Nasopharynx Microflora and Increases the Risk of Respiratory Diseases [J]. Frontiers in Microbiology, 2020, 11: 630280. (通讯作者,IF=5.640,2区top)

[14] GU X, MA Z, FANG J, et al.Obesity Enhances Antioxidant Capacity and Reduces Cytokine Levels of the Spleen in Mice to Resist Splenic Injury Challenged byEscherichia coli[J].Journal of Immunology Research, 2020, 2020: 5948256. (IF=4.818)

[15] WANG F, ZUO Z, YANG Z, et al.Delayed Pulmonary Apoptosis of Diet-Induced Obesity Mice following Infection through the Mitochondrial Apoptotic Pathway [J].Oxidative Medicine and Cellular Longevity, 2019, 2019: 1968539. (IF=6.543)

[16] WANG F, ZUO Z, CHEN K, et al.Selenium Rescues Aflatoxin B 1 -Inhibited T Cell Subsets and Cytokine Levels in Cecal Tonsil of Chickens [J]. Biological trace element research, 2019, 188(2):461-467.(IF=3.783)

[17] SONG H, ZUO Z, YANG Z, et al.Hepatic histopathology and apoptosis in diet-induced-obese mice under pneumonia [J].Aging (Albany NY), 2019, 11(9): 2836-51.(共同第一作者,IF=5.682,1区top)

[18] LI B, FANG J, HE T, et al.Resistin up-regulates LPL expression through the PPARγ-dependent PI3K/AKT signaling pathway impacting lipid accumulation in RAW264.7 macrophages [J].CYTOKINE, 2019, 119: 168-74.(通讯作者,IF=3.681)

[19] WANG F, ZUO Z, CHEN K, et al.Histopathological Injuries, Ultrastructural Changes, and Depressed TLR Expression in the Small Intestine of Broiler Chickens with Aflatoxin B1 [J].Toxins, 2018, 10(4): 131. (IF=4.546)

[20] REN Z, FAN Y, ZHANG Z, et al.Sodium selenite inhibits deoxynivalenol-induced injury in GPX1-knockdown porcine splenic lymphocytes in culture [J].Scientific Reports, 2018, 8(1):(IF=4.379)

[21] PING H, ZUO Z, HANG L, et al.The molecular mechanism of cell cycle arrest in the Bursa of Fabricius in chick exposed to Aflatoxin B [J]. Scientific Reports, 2018, 8(1): 1770. (IF=4.379)

[22] LI B, FANG J, ZUO Z, et al.Activation of the porcine alveolar macrophages via toll-like receptor 4/NF-κB mediated pathway provides a mechanism of resistin leading to inflammation [J]. CYTOKINE, 2018, 110: 357-66.(通讯作者,IF=3.681)

[23] JING F, ZHENG Z, YANG Z, et al.Ameliorative effects of selenium on the excess apoptosis of the jejunum caused by AFB1through death receptor and endoplasmic reticulum pathways [J].Toxicology Research, 2018, 10.1039.C8TX00068A-. (IF=3.542)

[24] HU P, ZUO Z, WANG F, et al.The Protective Role of Selenium in AFB 1 -Induced Tissue Damage and Cell Cycle Arrest in Chicken's Bursa of Fabricius [J]. BIOLOGICAL TRACE ELEMENT RESEARCH, 2018,(IF=3.783)

[25] FANG J, ZHU P, YANG Z, et al.Selenium Ameliorates AFB 1 Induced Excess Apoptosis in Chicken Splenocytes Through Death Receptor and Endoplasmic Reticulum Pathways [J]. BIOLOGICAL TRACE ELEMENT RESEARCH, 2018,(IF=3.783)

[26] FANG J, YIN H, ZHENG Z, et al.The Molecular Mechanisms of Protective Role of Se on the G/M Phase Arrest of Jejunum Caused by AFB [J]. BIOLOGICAL TRACE ELEMENT RESEARCH, 2018, 181(1): 142-53. (IF=3.783)

[27] FANG J, WANG F, SONG H, et al.AMPKα pathway involved in hepatic triglyceride metabolism disorder in diet-induced obesity mice following Escherichia coli Infection [J]. Aging (Albany NY), 2018, 10(11): (共同第一作者,IF=5.682,1区top)

[28]Histopathological Changes Caused by Inflammation and Oxidative Stress in Diet-Induced-Obese Mouse following Experimental Lung Injury [J]. Scientific Reports, 2018, (IF=4.379)

[29] ZHU P, ZUO Z, ZHENG Z, et al.Aflatoxin B1 affects apoptosis and expression of death receptor and endoplasmic reticulum molecules in chicken spleen [J]. Oncotarget, 2017, 8(59): 99531-40. (已不是SCI)

[30] ZHENG Z, ZUO Z, ZHU P, et al. A study on the expression of apoptotic molecules related to death receptor and endoplasmic reticulum pathways in the jejunum of AFB1-intoxicated chickens [J]. Oncotarget, 2017, 8(52): 89655-64.

[31] REN Y, WAN T, ZUO Z, et al.Resistin increases the expression of NOD2 in mouse monocytes [J]. Experimental & Therapeutic Medicine, 2017, (IF=2.447)

[32] LIU C, ZUO Z, ZHU P, et al. Sodium selenite prevents suppression of mucosal humoral response by AFB 1 in broiler's cecal tonsil [J]. Oncotarget, 2017, 8(33): 54215-26.

[33] LI B, FANG J, ZUO Z, et al.Activation of porcine alveolar macrophages by Actinobacillus pleuropneumoniae lipopolysaccharide via the TLR4/NF-κB mediated pathway [J]. Infection & Immunity, 2017, IAI.00642-17. (IF=3.441)

[34] WANG X, ZUO Z, ZHAO C, et al.Protective role of selenium in the activities of antioxidant enzymes in piglet splenic lymphocytes exposed to deoxynivalenol [J].ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2016, 47(53-61. (IF=4.860)

[35] WAN T, YUAN G, REN Y, et al.Diet-induced obese mice exhibit altered immune responses to acute lung injury induced by Escherichia coli [J].Obesity (Silver Spring), 2016, 24(10): 2101-10. (IF=5.002)

[36] YU S, YAN X, LIU H, et al.Improved establishment of embryonic stem (ES) cell lines from the Chinese Kunming mice by hybridization with 129 mice [J].INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2014, 15(3): 3389-402.(IF=5.923, 2区top)

[37] ZUO Z, CUI H, LI M, et al. Transcriptional profiling of swine lung tissue after experimental infection with Actinobacillus pleuropneumoniae [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 14(5): 10626-60.(第一作者,IF=5.923, 2区top)

[38] ZHICAI Z, DAI H, CHEN L, et al. Development and application of a polymerase chain reaction to early detect haemophilus parasuis [J]. Journal of Animal & Veterinary Advances, 2013, 12(2): 140-5.

[39] YU S, ZUO Z, CUI H, et al. Transcriptional profiling of hilar nodes from pigs after experimental infection with Actinobacillus pleuropneumoniae [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 14(12): 23516-32. (第一作者,IF=5.923, 2区top)

获奖、新药、新品种等

四川省科技进步三等奖1项;主研神农中华农业科技三等奖1项;四川省第八届高等教育优秀教学成果二等奖1项;获2021四川省教育系统优秀共产党员荣誉称号。

授权专利、编著教材

获授权专利34项;主编《小动物疾病临床诊疗技术》

社会服务

1.肉牛疫病诊断防控新技术研发。创制了“快速检测牛病毒性腹泻病毒抗原的胶体金试纸条”、“免疫增强因子-牛重组抵抗素”;筛选出抗BVDV中药单体(绞股蓝皂苷、淫羊藿苷)。若应用上述胶体金试纸条,可为万头繁育牛场节省检测及淘汰PI牛损失费用130万元/年。成功集成“犊牛腹泻的早期预防、诊断和精准治疗技术”并在新疆伊犁、四川宜宾和阿坝等地牛场示范应用,能提升犊牛存活率5~45%;以100头为例,犊牛0.5万元/头,提高犊牛存活率可获益2.5~22.5万元。

2.肉牛疾病防控技术推广。作为四川肉牛创新团队疾病岗位专家一直服务于四川肉牛牦牛养殖业,不时受邀赴重庆、贵州、新疆等地区开展肉牛牦牛疾病防控及相关技术培训,致力解决西南地区基层牛病防控缺医少药、防治规范差等问题。自2018年以来,组织肉牛牦牛疾病防控培训45次,培训肉牛牦牛从业人员4700余人次,获业界广泛认同。

3.牛病防治技术科普。利用微信群、QQ群以及四川农村日报专栏,向养殖户介绍动物防病治病方法和养殖技术诀窍,发稿80余篇,其中“牛病防治实用技术”34篇,受众达680万人(按日报发行量20万计算)。

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