导师类型

博导/硕导

办公地点

6-312

职称/职务

教授

电子邮箱

fuhl.sicau@163.com

研究方向

药物（兽药）新型给药系统的研究与应用

学术、技术组织任职/头衔

中国畜牧兽医学会兽医药理毒理学分会理事、动物药品学分会理事。

教育背景及工作经历

1995年本科毕业于4556银河国际线路测试兽医专业，2003年硕士毕业于4556银河国际线路测试基础兽医学中药药理专业，2009年博士毕业于四川大学华西药学院药剂学专业。

1995年7月于4556银河国际线路测试4556银河国际线路测试参加工作

教学课程

本科课程：药剂学、工业药剂学、现代药物传递系统概论、药用高分子材料学、药物制剂设计与评价

博士课程：高级兽医药理学与毒理学

人才培养情况

担任药物制剂专业负责人，至今指导药物制剂专业人才培养共19届。

培养硕士研究生已毕业40人，现有在读博士3人，硕士9人。

科研项目

（近五年）

药物制剂创新联合实验室（企业横向，2020-2023，到账经费15万）

产学研合作项目（企业横向，2021-2024，到账经费40万）

烯丙孕素缓释制剂项目（企业横向，2021-2024，到账经费12万）

烟雾消毒剂的安全性评价（企业横向，2021-2022，到账经费10万）

四川省科技厅苗子工程项目（2016，到账经费10万）

四川省三区人才支持项目（2015-2022，到账经费12万）

四川省兽药监察所兽药科技创新研究项目（2016，到账经费10万）

宠物新药研究（2017-2020，到账经费120万）

主要论著、

代表性论文

发表论文110余篇，其中SCI收录40余篇，CSCD收录论文30篇。

主要代表性论文：

1.Jingyuan Fu, Yuning Zhang, Shiyu Lin, Wei Zhang, Gang Shu, Juchun Lin, Haohuan Li,Funeng Xu, Huaqiao Tang, Guangneng Peng, Ling Zhao, Shiqi Chen andHualin Fu*.Strategies for Interfering With Bacterial Early Stage Biofilms. Frontiers in microbiology, 2021，12, 1339. (IF=5.6)

2.Shiyu Lin, Linlin Pei, Wei Zhang, Gang Shu, Juchun Lin, Haohuan Li, Funeng Xu,Huaqiao Tang, Guangneng Peng, Ling Zhao, Lizi Yin, Li Zhang, Ruoyue Huang, Shiqi Chen,Zhixiang Yuan,Hualin Fu*(2021). Chitosan-poloxamer-based thermosensitive hydrogels containing zinc gluconate/recombinant human epidermal growth factor benefit for antibacterial and wound healing. Materials Science and Engineering: C,2021，130, 112450. (IF=7.3)

3.Tingting Zhang, Shiqi Chen, Daiping Yin,Hualin Fu*, Gang Shu, Juchun Lin, Wei Zhang. Preparation and Evaluation of Emulsion Containing Vitamin A and Vitamin D3 and Pharmacodynamics Study in Mice[J]. Latin American Journal of Pharmacy, 2020 Mar 22; 39 (8): 1663-70.

4.Shiqi Chen, Quanjin Liu, Haibo Dou, Li Zhang, Linlin Pei, Rouyue Huang, Gang Shu, Zhixiang Yuan, Juchun Lin, Wei Zhang, Guangneng Peng, Zhijun Zhong, Lizi Yin, Ling Zhao,Hualin Fu*. Solubility and dissolution thermodynamic properties of Mequindox in binary solvent mixtures[J]. Journal of Molecular Liquids, 2020 Apr 1;(303):112619.

5.Ruoyue Huang, Yuning Zhanga, Yanli Zhang, Li Zhang, Linlin Pei, Gang Shu, Zhixiang Yuan, Juchun Lin, Guangneng Peng, Wei Zhang, Ling Zhao, Fei Shi, Hualin Fu*. Evaluation of the synergetic effect of Yupingfeng san and Flos Sophorae Immaturus based on free radical scavenging capacity[J]. Biomedicine & Pharmacotherapy, 2020 May 10 (128):110265.

6.Li Chen, Junxia Wei, Mengying An, Li Zhang, Shiyu Lin, Gang Shu, Zhixiang Yuan, Juchun Lin, Guangneng Peng, Xiaoxia Liang, Lizi Yin, Wei Zhang, Ling Zhao, Hualin Fu*. Casein nanoparticles as oral delivery carriers of mequindox for the improved bioavailability[J]. Colloids and Surfaces B: Biointerfaces, 2020 June 25 (195): 111221.

7.Linlin Pei, Wenzhu Yang, Jingyuan Fu, Mengxi Liu, Tingting Zhang, Dongbo Li, Ruoyue Huang, Li Zhang, Guangneng Peng, Gang Shu, Zhixiang Yuan, Juchun Lin, Wei Zhang, Zhijun Zhong, Ling Zhao, Hualin Fu*. Synthesis, Characterization, and Pharmacodynamics Study of Enrofloxacin Mesylate[J]. Drug Design, Development and Therapy, 2020 (14):715-730.

8.Tingting Zhang, Shiqi Chen, Haibo Dou, Quanjin Liu, Gang Shu, Juchun Lin, Wei Zhang, Guangneng Peng, Zhijun Zhong, Hualin Fu*. Novel glucosamine-loaded thermosensitive hydrogels based on poloxamers for osteoarthritis therapy by intra-articular injection[J]. Materials Science & Engineering C, 2020 August 11 (118):111352. (IF=7.3)

9.Guoqing Fan, Li Zhang, Yun Shen, Gang Shu, Zhixiang Yuan, Juchun Lin,Wei Zhang, Guangneng Peng, Zhijun Zhong, Lizi Yin1 & Hualin Fu*. Comparative muscle irritation and pharmacokinetics of florfenicol hydroxypropyl-β-cyclodextrin inclusion complex freeze-dried powder injection and florfenicol commercial injection in beagle dogs. Scientific Reports ,2019,( 9 ):16739

10.Ruo-yue Huang, Linlin Pei, QuanJin Liu, Shiqi Chen, Haibo Dou, Gang Shu, Zhi-xiang Yuan, Juchun Lin, Guangneng Peng, Wei Zhang and Hualin Fu*. Isobologram Analysis: A Comprehensive Review of Methodology and Current Research. Frontiers in Pharmacology,2019,10:1-12

11.Wen-Zhu Yang, Guo-Qing Fan, Ting-Ting Zhang, Dong-Bo Li, Lin-Lin Pei, Ruo-Yue Huang, Dai-Ping Yin, Li Zhang, Guang-Neng Peng, Gang Shu, Zhi-Xiang Yuan, Ju-Chun Lin, Wei Zhang, Zhi-Jun Zhong, Li-Zi Yin & HuaLin Fu*. Determination of the solubility and thermodynamic properties of albendazole in a binary solvent of ethanol and water.2019,(9):1-11

12.Dongbo Li, Shiqi Chen, Haibo Dou, Wenbin Wu, Quanjin Liu, Li Zhang, Yun Shen, Gang Shu,Zhixiang Yuan, Juchun Lin, Wei Zhang, Guangneng Peng, Zhijun Zhong, Lizi Yin, Hualin Fu*. Preparation of cefquinome sulfate cationic proliposome and evaluation of its efficacy on Staphylococcus aureus biofilm. Colloids and Surfaces B:Biointerfaces,2019,182(7):1-9

13.Mengxi Liu,Hualin Fu∗,Fengying Deng,. Double-coated enrofloxacin microparticles with chitosan and alginate: Preparation, characterization and taste-masking effect study.[J]. Carbohydrate Polymers, 2017, 170:247.(IF=4.8)

14.Li Zhang,Hualin Fu∗. Toltrazuril mixed nanomicelle delivery system based on sodium deoxycholate-Brij C20 polyethylene ether-triton x100: Characterization, solubility, and bioavailability study.[J]. Colloids & Surfaces B Biointerfaces, 2017, 163:125.(IF=3.887)

15.Li Zhang,Hualin Fu∗.The hydroxypropyl–β-cyclodextrin complexation of toltrazuril for enhancing bioavailability [J]. Drug Design, Development and Therapy 2018:12 583–589(IF=2.82)

16.Dan-dan REN,Hua-lin FU*. Preparation and Acute Toxicity Evaluation of Colistin Sulfate Gel [J]. Latin American Journal of Pharmacy. 2017,36 (12): 2494-2500 (if=0.298)

17.Zhi-xiang Yuan,Hualin Fu*, Targeting Strategies for Renal Cell Carcinoma: From Renal Cancer Cells to Renal Cancer Stem Cells. Frontiers in Pharmacology, 2016, 7(194):423-437. ( IF=4.418)

18.Chao JIN，Hualin FU*. Synthesis, Characterization and Pharmacodynamics Studies of a Co-Drug Containing Paracetamol and Ibuprofen[J]. Latin American Journal of Pharmacy,, 2016, 35(2): 217-225.

19.Jianyu ZHOU,Hualin FU*. Solubilization and Intestinal Permeability Studies of Poloxamers in the Absence and Presence of Sodium Deoxycholate on a Poorly Water-Soluble Compound[J]. Latin American Journal of Pharmacy, 2016, 35(2): 312-329.

20.Chaocheng Lu,Hualin Fu*. Novel thermosensitivein situgel based on poloxamer for uterus delivery[J]. European Journal of Pharmaceutical Sciences, 2015, 77: 24–28.

21.Xue-Yan Qing,Hua-Lin Fu*. Solubility and Solution Thermodynamics of Diphenoxylate in Different Pure Solvents[J]. Journal of Chemical & Engineering Data, 2015, 60(6): 1629-1633.

22.Meng-jiao Liu,Hua-lin Fu*,. Measurement and Correlation of the Solubility of Enrofloxacin in Different Solvents from (303.15 to 321.05) K[J]. Journal of Chemical & Engineering Data, 2014, 59(6): 2070-2074.

23.Jianyu Zhou,Hualin Fu*. Solubility and solution thermodynamics of flofenicol in binary PEG 400 + water systems[J]. Fluid Phase Equilibria, 2014, 376(6): 159-164.

24.Meng-jiao Liu,Hua-lin Fu*. Solid–liquid equilibrium of azithromycin in water + 1, 2-propanediol solutions from (289.35 to 319.15) K [J]. Journal of Molecular Liquids, 2014, 199: 51-56.

25.Hang CAO,Hualin FU*.Preparation, Characterization and Pharmacokinetics of HPMC modified Florfenicol Microcrystals [J]. Latin American Journal of Pharmacy, 2014, 33(9): 1540-1546.

26.Mengjiao Liu，Hualin Fu*. A New Kinetic Approach. Stability of Cefquinome Sulfate under Variable pH and Temperature[J]. Indian Journal of Pharmaceutical Education and Research, 2014, 48: 27-33.

获奖、新药、新品种等

从事宠物药品研发，获得新兽药临床批件2项。

指导挑战杯、创青春、互联网+等双创项目获省级奖项（近五年，注获奖时间）

指导本科生龚松林等8位同学获得第十四届挑战杯四川省大学生课外学术科技作品竞赛一等奖和校级挑战杯竞赛一等奖（2017年）

指导学生参加全国药苑论坛获得创新成果三等奖（2019年）

创新实验、科研兴趣计划项目（近五年，注立项时间）

指导省级大学生创新性训练计划项目两项（2021年、2022年）

指导科研兴趣计划项目8项（2017-2021年）

授权专利、编著教材

申请专利51项，授权25项。代表性专利：

1、一种氟苯尼考包合物冻干粉针剂及其制备方法（ZL201910696991 .4）

2、一种氟苯尼考速溶性微粒及其制备方法（ZL201910074773.7）

3、兽用盐酸多西环素高分子复合物微粒及其制备方法，专利号：2011104392592

4、对乙酰氨基酚琥珀酸单酯的合成方法，专利号：2012101906423

5、一种制备氟苯尼考微晶体的方法，专利号：2013100995570

6、一种氟苯尼考磷酸酯的合成方法，专利号：2015106111074

7、一种恩诺沙星复层高分子矫味骨架微粒及其制备方法，专利号：2015105307398

教材：

1、副主编《兽医药剂学实验指导》（协编教材），中国农业出版社 ，2012.08

2、副主编《畜牧兽医行政管理学》，西南师范大学出版社，2013.8

社会服务

先后在国内多家兽药制剂企业担任研发顾问，为兽药企业开发新产品20余个，为兽药企业进行兽药产工艺技术改造100多项。