导师类型

办公地点

6-208

职称/职务

讲师

电子邮箱

sicau_heyu@163.com

研究方向

1.禽黄病毒的复制机制、跨宿主传播和适应机制

2.水禽新型病毒疫苗的研制

受教育及

工作经历

2012.09 - 2016.06 4556银河国际线路测试4556银河国际线路测试动植物检疫专业，理学学士

2016.09 - 2022.12 4556银河国际线路测试4556银河国际线路测试预防兽医学专业，农学博士（硕博连读）

2021.12 - 2022.11 新加坡南洋理工大学李光前医学院，联合培养

2023年1月-今 4556银河国际线路测试4556银河国际线路测试，讲师

科研项目

（近五年）

自然科学基金青年基金：坦布苏病毒基因组RNA重组模式及其关键调控因子的研究，2024-2026年，主持

主要论著、

代表性论文

[1]HE Y, GUO J, WANG X, et al. Assembly-defective Tembusu virus ectopically expressing capsid protein is an approach for live-attenuated flavivirus vaccine development [J].npj Vaccines, 2022, 7(1): 51.(一区，第一作者)

[2]HE Y, WANG X, GUO J, et al. Replication/assembly defective avian flavivirus with internal deletions in the capsid can be used as an approach for living attenuated vaccine [J].Front Immunol, 2021, 12: 694959. (二区Top，第一作者)

[3]HE Y, WANG M, CHEN S, et al. The role of capsid in the flaviviral life cycle and perspectives for vaccine development [J].Vaccine, 2020, 38(44): 6872-6881.（二区Top，第一作者)

[4]HE Y, LIU P, WANG T, et al. Genetically stable reporter virus, subgenomic replicon and packaging system of duck Tembusu virus based on a reverse genetics system [J].Virology, 2019, 533: 86-92. (三区，第一作者)

[5]HE Y, WANG A, CHEN S, et al. Differential immune-related gene expression in the spleens of duck Tembusu virus-infected goslings [J].Vet Microbiol, 2017, 212: 39-47. (二区Top，第一作者)

[6] CHEN S,HE Y, ZHANG R, et al. Establishment of a reverse genetics system for duck Tembusu virus to study virulence and screen antiviral genes [J].Antiviral Res, 2018, 157: 120-127.（共同一作）

[7] WANG X,HE Y, GUO J, et al. Comparative study of the pathogenicity of the mosquito origin strain and duck origin strain of Tembusu virus in ducklings and three-week-old mice.Virol Sin.2023. doi: 10.1016/j.virs.2023.07.006. （共同一作）

[8] GUO J,HE Y, WANG X, et al. Attenuation of Avian Flavivirus by Rewiring the Leucine and Serine Codons of Its E-NS1 Protein toward Stop Mutation To Redirect Virus Evolution [J].Microbiology Spectrum, 2023, 11(1): e02921-02922.（共同一作）

[9] MAO L,HE Y, WU Z, et al. Stem-Loop I of the Tembusu Virus 3′-Untranslated Region Is Responsible for Viral Host-Specific Adaptation and the Pathogenicity of the Virus in Mice [J].Microbiology Spectrum, 2022, 10(5): e02449-02422.（共同一作）

[10] WANG X,HE Y, GUO J, et al. Construction of an infectious clone for mosquito-derived Tembusu virus prototypical strain [J].Virol Sin, 2021, 36: 1678-1681. （共同一作）

[11] GUO J,HE Y, WANG X, et al. Stabilization of a full-length infectious cDNA clone for duck Tembusu virus by insertion of an intron [J].J Virol Methods, 2020, 283: 113922.（共同一作）

[12] CHEN S, LIU P,HE Y, et al. The 164 K, 165 K and 167 K residues in 160YPVVKKPKLTEE171 are required for the nuclear import of goose parvovirus VP1 [J].Virology, 2018, 519: 17-22.（共同一作）

授权专利、编著教材

①ZL201710702634.5，携带海肾荧光素酶的鸭坦布苏报告病毒的制备方法及其产品和应用，排名第二

②ZL201811402998.2，一种鸭坦布苏报告病毒的制备方法及其产品和应用，排名第二；

③ZL202110533132.0，一种鸭坦布苏病毒弱毒株及其制备方法和应用，排名第二

④ZL202110533162.1，一种鸭坦布苏病毒致弱活疫苗候选株及其制备方法和应用，排名第二

⑤ZL202111308597.2，一种鸭坦布苏病毒质粒载体、弱毒株及其制备方法和应用，排名第二